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Plasma Biomarkers for Age-Related Macular Degeneration
| Title: | Plasma Biomarkers for Age-Related Macular Degeneration |
| Author: | NI, JIAQIAN |
| Description: | The goal of this thesis research was to develop methods to predict susceptibility to age-related macular degeneration (AMD). Age-related macular degeneration (AMD) is the most common cause of legal blindness in the elderly in developed countries, and early identification of susceptibility is important for preventing this progressive disease. New and original evidence was found supporting the prognostic potential of plasma advanced glycation endproducts (AGEs) as possible biomarkers for AMD, specifically the oxidative protein modifications Nε-(carboxymethyl)lysine (CML) and pentosidine. Quantitative analyses of plasma from AMD (n = 60) and normal control (n = 30) donors showed that mean CML and pentosidine levels were elevated in AMD plasma by ~ 60% and ~ 80%, respectively, while furosine was largely unchanged. Another type of oxidative modification, carboxyethylpyrrole (CEP) adducts, were found to be ~ 2-fold higher in AMD (n = 56) than in controls (n = 30), consistent with previous findings. C-statistics were determined from receiver operating characteristic curves that indicate for these plasma samples, CML discriminated between AMD and control donors with ~ 80% accuracy, CEP adducts with ~ 81% and pentosidine with ~ 92% accuracy. In combination with CEP, CML provided ~ 89% accuracy and pentosidine provided ~ 95% discrimination accuracy. Overall, these results provided evidence that CML and pentosidine are both elevated in AMD plasma and may prove useful for predicting AMD susceptibility and for monitoring AMD therapeutics, especially in combination with CEP biomarkers. |
| Permanent Link: |
http://rave.ohiolink.edu/etdc/view?acc_num=csu1236700270
http://hdl.handle.net/2374.OX/104995 |
| Date: | 2009 |
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