Towards the Synthesis of N-Acetyl-2-amino-2-deoxy-D-mannopyranose uronic acid (D-ManNAcA) and Derivatives

 
 
 
 

Towards the Synthesis of N-Acetyl-2-amino-2-deoxy-D-mannopyranose uronic acid (D-ManNAcA) and Derivatives

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dc.contributor.advisor Norris, Peter en_US
dc.contributor.author Cox, Glen Adam en_US
dc.date.accessioned 2009-04-10T08:16:00Z
dc.date.available 2009-04-10T08:16:00Z
dc.date.created 2007 en_US
dc.date.issued 2009-04-10T08:16:00Z
dc.identifier.uri http://rave.ohiolink.edu/etdc/view?acc_num=ysu1217344144 en_US
dc.identifier.uri http://hdl.handle.net/2374.OX/107935
dc.description The following details attempts at a stereoselective synthesis of deoxygenated D-mannose uronic acid derivatives from D-glucurono-6,3-lactone. These derivatives will be tested as potential inhibitors of enzymes used by Staphylococcus aureus to form its polysaccharide microcapsule, which functions as a protective barrier against destruction by the host. Two serotypes (types 5 and 8) comprise the majority of S. aureus bacteria and also the most virulent strains of this bacterium. The goal of this research project is to synthesize glycomimetics of D-ManNAcA that may act as potential inhibitors of the enzymes such as UDP-GlcNAc 2-epimerase. Since infections caused by S. aureus are an increasing threat in hospitals and the general community, it is of considerable interest within the biological community to find new treatments to combat these drug-resistant bacteria. en_US
dc.format application/pdf en_US
dc.format xiii, 213p. en_US
dc.rights unrestricted en_US
dc.rights Copyright and permissions information available at the source archive en_US
dc.subject carbohydrate en_US
dc.subject S. aureus en_US
dc.subject glycobiology en_US
dc.subject capsular polysaccharide en_US
dc.title Towards the Synthesis of N-Acetyl-2-amino-2-deoxy-D-mannopyranose uronic acid (D-ManNAcA) and Derivatives en_US
dc.type Electronic Thesis or Dissertation en_US
dc.degree.name MS en_US
dc.degree.level masters en_US
dc.degree.discipline Chemistry en_US
dc.degree.grantor Youngstown State University en_US
dc.contributor.publisher Youngstown State University / OhioLINK en_US

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