Towards the Synthesis of N-Acetyl-2-amino-2-deoxy-D-mannopyranose uronic acid  (D-ManNAcA) and Derivatives

Title:	Towards the Synthesis of N-Acetyl-2-amino-2-deoxy-D-mannopyranose uronic acid (D-ManNAcA) and Derivatives
Author:	Cox, Glen Adam
Description:	The following details attempts at a stereoselective synthesis of deoxygenated D-mannose uronic acid derivatives from D-glucurono-6,3-lactone. These derivatives will be tested as potential inhibitors of enzymes used by Staphylococcus aureus to form its polysaccharide microcapsule, which functions as a protective barrier against destruction by the host. Two serotypes (types 5 and 8) comprise the majority of S. aureus bacteria and also the most virulent strains of this bacterium. The goal of this research project is to synthesize glycomimetics of D-ManNAcA that may act as potential inhibitors of the enzymes such as UDP-GlcNAc 2-epimerase. Since infections caused by S. aureus are an increasing threat in hospitals and the general community, it is of considerable interest within the biological community to find new treatments to combat these drug-resistant bacteria.
Permanent Link:	http://rave.ohiolink.edu/etdc/view?acc_num=ysu1217344144 http://hdl.handle.net/2374.OX/107935
Date:	2007

Files in this item

Files	Size	Format	View
There are no files associated with this item.