Synthesis and Reactions of bis(2,2,2-Trifluoroethyl)-β-Ketophosphonates

Title:	Synthesis and Reactions of bis(2,2,2-Trifluoroethyl)-β-Ketophosphonates
Author:	White, Kevin Michael
Description:	The research contained herein is focused on a previously unreported synthesis of bis(2,2,2-trifluoroethoxy)-β-ketophosphonates via the hydration of the corresponding bis(2,2,2-trifluoroethoxy) alkynylphosphonates. The first step was to prepare all starting materials, namely the bis(2,2,2-trifluoroethyl) alkynylphosphonates from the corresponding commercially available terminal alkynes and bis(2,2,2-trifluoethoxy) phosphorochloridate. The hydration of the bis(2,2,2-trifluoroethoxy) alkynylphosphonates to yield the desired products was accomplished using mercury sulfate and 10% sulfuric acid. 2,2,2-Trifluoethanol was used as the solvent. The use of these β-keto phosphonates in the Horner-Wadsworth-Emmons reaction was also examined.
Permanent Link:	http://rave.ohiolink.edu/etdc/view?acc_num=ysu1220828375 http://hdl.handle.net/2374.OX/107937
Date:	2008

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