Identification of Candidate Genes within Blood Pressure QTL Containing Regions Using Gene Expression Data

 
 
 
 

Identification of Candidate Genes within Blood Pressure QTL Containing Regions Using Gene Expression Data

Show simple item record


dc.contributor.advisor Cicila, George en_US
dc.contributor.author McSweeny, Andrew J. en_US
dc.date.accessioned 2008-07-10T16:37:38Z
dc.date.available 2008-07-10T16:37:38Z
dc.date.created 2008 en_US
dc.date.issued 2008-07-10T16:37:38Z
dc.identifier.uri http://rave.ohiolink.edu/etdc/view?acc_num=mco1212501779 en_US
dc.identifier.uri http://hdl.handle.net/2374.OX/18078
dc.description Hypertension is a polygenic disorder where many genes control expression of blood pressure (BP). A large portion of cases are salt-sensitive. Finding genes controlling BP will yield insight into the pathophysiology of hypertension. Interval mapping in the Dahl rat model of salt-sensitive hypertension allows control of genetic and environmental factors affecting BP expression and location of novel BP quantitative trait loci (QTL), genomic regions containing genes regulating BP. Substitution mapping with congenic strains and substrains achieves QTL boundary reduction. Analysis of gene expression data from kidneys of S rats and congenic rats allows selection of BP candidate genes; two such studies are presented. The first is after 28 days of an elevated dietary salt intake. The second is after 24 hours wherein half the rats had an elevated dietary salt intake. Candidate genes identified by both studies include Dnajc5, Edn3, Pol3rk, Psma7, and Rtel1. en_US
dc.format application/pdf en_US
dc.format 233p. en_US
dc.rights unrestricted en_US
dc.rights Copyright and permissions information available at the source archive en_US
dc.subject Dahl rat en_US
dc.subject microarray en_US
dc.subject blood pressure en_US
dc.subject hypertension en_US
dc.subject gene epxression en_US
dc.subject congenic en_US
dc.title Identification of Candidate Genes within Blood Pressure QTL Containing Regions Using Gene Expression Data en_US
dc.type Electronic Thesis or Dissertation en_US
dc.degree.name MS en_US
dc.degree.level masters en_US
dc.degree.discipline Graduate Studies en_US
dc.degree.grantor University of Toledo Health Science Campus en_US
dc.contributor.publisher University of Toledo Health Science Campus / OhioLINK en_US

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record