Interactions Between Aldosterone, Spironolactone and the Cardiotonic Steroids

 
 
 
 

Interactions Between Aldosterone, Spironolactone and the Cardiotonic Steroids

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dc.contributor.advisor Shapiro, Joseph en_US
dc.contributor.author Shidyak, Amjad en_US
dc.date.accessioned 2008-07-10T16:40:03Z
dc.date.available 2008-07-10T16:40:03Z
dc.date.created 2008 en_US
dc.date.issued 2008-07-10T16:40:03Z
dc.identifier.uri http://rave.ohiolink.edu/etdc/view?acc_num=mco1206043131 en_US
dc.identifier.uri http://hdl.handle.net/2374.OX/18138
dc.description We have reported that rats subjected to partial nephrectomy (PNx) or administration of marinobufagenin (MBG) developed an increase in blood pressure, heart size, diastolic dysfunction, and cardiac fibrosis. Spironolactone (S) has been demonstrated to attenuate cardiac fibrosis in both experimental animals and humans with heart failure. We investigated the effects of treatment of S in the cardiomyopathy. Rats were divided into four groups: one group PNx and a second group sham surgery (C), placement of a minipump of S in another group and PNx + S in the final group. Rats were studied at 4 wk. PNx rats had higher systolic blood pressure, cardiac fibrosis than C. S did not differ significantly from C. PNx +. S had substantially attenuated cardiac growth and fibrosis and decreased blood pressure (all p<0.01). These data suggest that S antagonizes MBG induced signaling which leads to cardiac fibrosis in the PNx model and raises the tantalizing question whether this mechanism explains at least part of the clinical beneficial effects of S on cardiac fibrosis in this and other settings. en_US
dc.format application/pdf en_US
dc.format 50p. en_US
dc.rights unrestricted en_US
dc.rights Copyright and permissions information available at the source archive en_US
dc.title Interactions Between Aldosterone, Spironolactone and the Cardiotonic Steroids en_US
dc.type Electronic Thesis or Dissertation en_US
dc.degree.name MS en_US
dc.degree.level masters en_US
dc.degree.discipline Graduate Studies en_US
dc.degree.grantor University of Toledo Health Science Campus en_US
dc.contributor.publisher University of Toledo Health Science Campus / OhioLINK en_US

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