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KINETICS AND PASSIVE PROTECTION EFFICACY INDUCED BY PURIFIED AVA HUMAN IMMUNOGLOBULIN G IN RABBITS AGAINST A Bacillus anthracis AEROSOL CHALLENGE
| Title: | KINETICS AND PASSIVE PROTECTION EFFICACY INDUCED BY PURIFIED AVA HUMAN IMMUNOGLOBULIN G IN RABBITS AGAINST A Bacillus anthracis AEROSOL CHALLENGE |
| Author: | Plahovinsak, Jennifer Lee |
| Description: | The present study was conducted to determine the half-life, assess the toxicity, and passive protection efficacy of purified immunoglobulin G (IgG) from Anthrax Vaccine Adsorbed (AVA) vaccinated human donors. Half-life determinations were calculated from the reportable values obtained using the anti-PA ELISA assay and the Centers for Disease Control’s (CDC) “ELISA for Windows” software. For toxicity evaluations animals were observed clinical for one hour post administration and for 14-days post-treatment. The protection efficacy was determined based upon the mortality results from a lethal Bacillus anthracis aerosol challenge. While no protection was achieved in this delayed exposure scenario, the study yielded valuable kinetics data for use in future research. |
| Permanent Link: |
http://rave.ohiolink.edu/etdc/view?acc_num=wright1166813637
http://hdl.handle.net/2374.OX/19493 |
| Date: | 2006 |
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