Feasibility of Radiographic Absorptiometry of the Mandible as an Osteoporosis Screening Method

 
 
 
 

Feasibility of Radiographic Absorptiometry of the Mandible as an Osteoporosis Screening Method

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dc.contributor.advisor Hangartner, Thomas N. en_US
dc.contributor.author Skipper, Julie A. en_US
dc.date.accessioned 2008-07-11T14:56:03Z
dc.date.available 2008-07-11T14:56:03Z
dc.date.created 2003 en_US
dc.date.issued 2008-07-11T14:56:03Z
dc.identifier.uri http://rave.ohiolink.edu/etdc/view?acc_num=wright1057695994 en_US
dc.identifier.uri http://hdl.handle.net/2374.OX/19671
dc.description The purpose of this work was to develop and evaluate single- and dual-energy radiographic absorptiometry (RA) for the measurement of mandibular bone mineral density (BMD), using standard dental equipment, that would allow for inexpensive and widespread osteoporosis screening. Accurately measured x-ray tube spectra are important for validating the simulations used in the design of the method. A constrained least-squares deconvolution technique for reducing the detector-induced blurring of the energy spectrum was developed. Application of this analytic correction to spectra acquired with a NaI-photomultiplier detector improved the measured data by 20-60%. Implementation of the screening method is accomplished by simultaneously acquiring high- and low-energy images on a single dental radiograph by appropriate filtering of the dental x-ray tube output. Computer simulations were performed to optimize the filters with respect to error in the bone measurement. A custom-designed film holder houses the beam filters and accommodates calibration wedges that allow the radiographs to be normalized for differences in exposure and developing conditions. Forty-six male and female subjects, ages 27 to 87 years, participated in a pilot study to assess the RA techniques. Left and right vertical periapical radiographs were taken of the premolar-molar region and, for comparison, the subjects’ BMD was evaluated at the spine, left and right femur as well as total body by dual-energy x-ray absorptiometry (DXA). Mandibular BMD by either high or low single-energy RA measurements was positively correlated with skeletal BMD, as assessed by DXA, at the arms, legs, trunk, ribs, pelvis, total body and femoral neck. ROC analysis of the single-energy techniques for identification of osteopenic and osteoporotic female subjects, as defined by DXA at the left femoral neck, yielded an area under the curve of 0.73. This is comparable to commercial devices currently used for screening and indicates that the RA method may be valuable for early diagnosis of low bone mass. en_US
dc.format application/pdf en_US
dc.format 66p. en_US
dc.rights unrestricted en_US
dc.rights Copyright and permissions information available at the source archive en_US
dc.subject bone mineral density en_US
dc.subject mandible en_US
dc.subject osteoporosis en_US
dc.subject radiographic absorptiometry en_US
dc.subject spectral measurement en_US
dc.title Feasibility of Radiographic Absorptiometry of the Mandible as an Osteoporosis Screening Method en_US
dc.type Electronic Thesis or Dissertation en_US
dc.degree.name PhD en_US
dc.degree.level doctoral en_US
dc.degree.discipline Biomedical Sciences PhD en_US
dc.degree.grantor Wright State University en_US
dc.contributor.publisher Wright State University / OhioLINK en_US

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