Studies Toward the Synthesis of Aminosugars Related to Components of the S. aureus Capsular Polysaccharide

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Title:	Studies Toward the Synthesis of Aminosugars Related to Components of the S. aureus Capsular Polysaccharide
Author:	Fluxe, Andrew James
Description:	The following work describes new synthetic pathways toward one of the monosaccharide units, and analogs thereof, of the Staphylococcus aureus Type 5 and Type 8 capsular polysaccharides. Two main approaches to N-acetyl-D-mannosamine uronic acid were investigated. The first method utilized dithioacetal chemistry in which a pentose sugar was extended by one carbon atom via a nucleophilic addition to afford a hexose sugar derivative. The second synthetic procedure involved the addition of various nucleophiles to a selective protected D-mannosamine derivative to afford progenitors of D-ManAcA analogs.
Permanent Link:	http://rave.ohiolink.edu/etdc/view?acc_num=ysu1008343078 http://hdl.handle.net/2374.OX/2993
Date:	2001

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