Estrogen modulation of MPP ^+ - induced Dopamine secretion in the Corpus Striatum and Nucleus accumbens of the Rat Brain

 
 
 
 

Estrogen modulation of MPP ^+ - induced Dopamine secretion in the Corpus Striatum and Nucleus accumbens of the Rat Brain

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dc.contributor.advisor Leipheimer, Robert E. en_US
dc.contributor.author Arvin, Michael, Jr. en_US
dc.date.accessioned 2008-06-30T15:37:13Z
dc.date.available 2008-06-30T15:37:13Z
dc.date.created 1998 en_US
dc.date.issued 2008-06-30T15:37:13Z
dc.identifier.uri http://rave.ohiolink.edu/etdc/view?acc_num=ysu997203042 en_US
dc.identifier.uri http://hdl.handle.net/2374.OX/3049
dc.description Parkinson’s disease, first described in 1817, is a progressive disorder affecting men and women of middle age and older. The disease results in a disruption of normal motor function. Classic features include muscle rigidity, resting tremor, and the inability to initiate normal muscle movement. These symptoms are the result of the destruction of dopamine producing neurons in an area of the brain known as the Substantia Nigra and the subsequent depletion of dopamine in the striatum. The cause of the disorder is still unknown. Possible contributing factors proposed include environmentally acquired toxins, and/or endogenous toxic metabolic byproducts. There is also the possibility of a genetic component predisposing certain individuals to the disorder. This study was designed to investigate the modulatory and possible neuroprotective effects of the steroid hormone estrogen upon dopamine release and clearance from neurons of the nigrostriatal system. An in vivo animal model, along with the technique of in vivo electrochemistry was used to demonstrate, in real time, the characteristics of dopamine release and clearance. This is accomplished through the use of a stereotaxic instrument which allows for the placement of an electrode and micropipette assemble into specific brain regions. A neurotoxin, MPP -1 , which stimulates the biochemical events seen in Parkinson’s disease was used to stimulate the release of dopamine from the nigrostriatal neurons. Female ovarectomized rats were divided into two treatment groups, MPP ^+ alone, and MPP ^+ with estrogen. These treatments were applied to the rat forebrain and measurement of the ensuing dopamine release were monitored using the IVEC-10 system and software capable of measuring neurochemical substances such as dopamine. Results of this study demonstrate a modulatory and/or neuroprotective effect of estrogen upon neurons of the nigrostriatal pathway by decreasing the effectiveness of MPP ^+ to elicit the release of dopamine from these neurons. The results of this study also reveal differences, in some release and clearance parameters, between the corpus striatum and nucleus accumbens. en_US
dc.format application/pdf en_US
dc.format viii, 159 leaves en_US
dc.rights unrestricted en_US
dc.rights Copyright and permissions information available at the source archive en_US
dc.subject Parkinson's Disease en_US
dc.subject dopamine en_US
dc.subject MPP ^+ en_US
dc.subject nucleus accumbens en_US
dc.title Estrogen modulation of MPP ^+ - induced Dopamine secretion in the Corpus Striatum and Nucleus accumbens of the Rat Brain en_US
dc.type Electronic Thesis or Dissertation en_US
dc.degree.name MS en_US
dc.degree.level masters en_US
dc.degree.discipline Biological Sciences en_US
dc.degree.grantor Youngstown State University en_US
dc.contributor.publisher Youngstown State University / OhioLINK en_US

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