Role of the RB-E2F pathway in embryonic development: implications for paradigms of cell cycle control

 
 
 
 

Role of the RB-E2F pathway in embryonic development: implications for paradigms of cell cycle control

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Title: Role of the RB-E2F pathway in embryonic development: implications for paradigms of cell cycle control
Author: Wenzel, Pamela L.
Description: The Rb-E2F pathway has been the focus of a tremendous body of research, due in large part to its well-recognized role in tumorigenesis. We report in this study a role for Rb in limiting proliferation of trophoblast stem cells during development of the mouse placenta. These findings point to a critical role for Rb at a time when stem cells are beginning to differentiate. We also address the role of Rb binding partners, E2F1, E2F2, and E2F3, in stem and progenitor cell biology in vivo and in vitro. We find that these transcriptional activators are largely dispensable for proliferation in pluripotent stem cells and in many differentiated cell types; however, E2F1-3 do appear to be critical for cell cycle regulation and survival during and after differentiation of specific lineages. Further, we explore the implications of our findings for the current paradigm of E2F function and consider novel roles for E2F that may be largely independent of transcriptional control of cell cycle-regulated gene expression. Appreciating how these genes function in stem cells will be key to understanding how they impact the cell cycle, senescence, self-renewal, proliferation, apoptosis, and differentiation programs during normal development and tumorigenesis.
Permanent Link: http://rave.ohiolink.edu/etdc/view?acc_num=osu1179341665
http://hdl.handle.net/2374.OX/5237
Date: 2007

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