THE EFFECTS OF NOISE EXPOSURE AT VARIOUS AGES ON AHL GENE EXPRESSION

 
 
 
 

THE EFFECTS OF NOISE EXPOSURE AT VARIOUS AGES ON AHL GENE EXPRESSION

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Title: THE EFFECTS OF NOISE EXPOSURE AT VARIOUS AGES ON AHL GENE EXPRESSION
Author: NOLTE, MANDEE L
Description: C57BL/6J (B6) mice are the experimental model for presbycusis, and have been shown to be more susceptible to noise-induced hearing loss. The congenic B6-Cast mouse is genetically identical to the B6 strain, except that the Ahl gene has been replaced with a wild-type, gene for normal hearing. As a result, B6-Cast mice are thought to be resistant to the effects of aging and noise. The purpose of this study is to assess the effects of noise-exposure at specific ages on the expression of the Ahl gene. Results indicate that both strains of mice actually exhibit presbycusis and noise-induced hearing loss, but the B6-Cast strain develop hearing loss at a slower pace compared to the B6 strain. These results suggest that there is at least one other gene, other than Ahl, in the background of the B6 mice that contributes to the hearing losses experienced in this study.
Permanent Link: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1116270875
http://hdl.handle.net/2374.OX/9323
Date: 2005

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